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搜索结果包含 medicilon 的内容

Oct 10,2023
美迪西助力备受瞩目,第21届圣地亚哥生物制药论坛圆满落幕
2023年9月30日中秋佳节,南加生物医学和制药促进会 (SABPA)成功举办了第21届圣地亚哥生物制药论坛,陈春麟博士受邀发表了“Retrospective Studies on New Drug Research in China based on IND Approval Cases at Medicilon”精彩演讲。
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美迪西助力备受瞩目,第21届圣地亚哥生物制药论坛圆满落幕
Sep 25,2023
9月30日,美迪西陈春麟博士将出席第21届圣地亚哥生物制药大会
美迪西创始人&CEO陈春麟博士将出席第21届圣地亚哥生物制药大会,并带来主题演讲:“Retrospective Studies on New Drug Research in China based on IND Approval Cases at Medicilon”
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9月30日,美迪西陈春麟博士将出席第21届圣地亚哥生物制药大会
Jul 06,2023
基于构效关系分析,合成了一种结构简化但具有优异防污活性的化合物。优化后的化合物通过美迪西合成
Biofouling poses one of the most serious problems to marine industry and aquaculture development. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces stra
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基于构效关系分析,合成了一种结构简化但具有优异防污活性的化合物。优化后的化合物通过美迪西合成
Jul 06,2023
AD80是一种多激酶抑制剂,在多种肝细胞癌临床前动物模型中具有抗肿瘤活性,AD80在血浆中的含量通过美迪西进行LC-MS/MS测定
Liver cancer is the fourth greatest cause of cancer related mortality. AD80 is a multi-kinase inhibitor with anti-tumoral activity across a variety of hepatocellular carcinoma (HCC) preclinical models
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AD80是一种多激酶抑制剂,在多种肝细胞癌临床前动物模型中具有抗肿瘤活性,AD80在血浆中的含量通过美迪西进行LC-MS/MS测定
Jun 28,2023
SAHA可有效恢复阿尔茨海默病模型的记忆能力,本研究中SAHA通过美迪西合成
SAHA was synthesized by Medicilon and was given to mice as 50 mg/kg doses. Injections (10 mL/kg) were given intraperitoneally and were alternated daily between left and right sides of the abdomen. Chronic treatments of SAHA completely restored performance
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SAHA可有效恢复阿尔茨海默病模型的记忆能力,本研究中SAHA通过美迪西合成
Jun 28,2023
TAK-243是一种有效的泛素激活酶小分子抑制剂,具有体内抗肿瘤功效,通过美迪西使用HCC70模型进行
TAK-243 is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade. TAK-243 has UAE-specific antitumor efficacy in vivo. Medicilon perfor
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TAK-243是一种有效的泛素激活酶小分子抑制剂,具有体内抗肿瘤功效,通过美迪西使用HCC70模型进行
Jun 28,2023
法尼基转移酶抑制剂LNK-754单次口服后即可快速穿过血脑屏障,PK分析通过美迪西进行
Pharmacokinetic studies revealed that after a single oral dose, the FTI (LNK-754) was cleared from plasma within 20 hours and could rapidly cross the blood-brain-barrier. Pharmacokinetic analysis was performed as a service provided by Medicilon.
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法尼基转移酶抑制剂LNK-754单次口服后即可快速穿过血脑屏障,PK分析通过美迪西进行
Jun 28,2023
WYC-209可抑制恶性小鼠黑色素瘤肿瘤再生细胞增殖,SPR分析通过美迪西使用Biacore 8K设备进行
The binding assay by surface plasmon resonance (SPR) analysis shows that WYC-209A and WYC-209B acid bind to RARs at nano-molar doses. SPR was carried out by Medicilon, using the Biacore 8K equipment.
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WYC-209可抑制恶性小鼠黑色素瘤肿瘤再生细胞增殖,SPR分析通过美迪西使用Biacore 8K设备进行
Jun 28,2023
ARD-2128是一种PROTAC AR降解剂,具有出色的血浆和微粒体稳定性,体外稳定性和PK研究通过美迪西进行
ARD-2128 has excellent plasma and microsomal stability in all the five species (Human, Mouse, Rat, Dog, and Monkey). The in vitro stability and pharmacokinetic (PK) studies were performed by Medicilon.
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ARD-2128是一种PROTAC AR降解剂,具有出色的血浆和微粒体稳定性,体外稳定性和PK研究通过美迪西进行
Jun 28,2023
开发并验证新的LC-MS/MS方法,用于定量人血浆中达拉非尼及其主要代谢物羟基达拉非尼 (OHD)。OHD(纯度>99%)通过美迪西合成
OHD (purity >99 %) was synthesized by Medicilon. Medicilon synthetic chemistry team is capable of the independent design of synthesis pathways and complex compound treatments, key to helping accelerate drug discovery.
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开发并验证新的LC-MS/MS方法,用于定量人血浆中达拉非尼及其主要代谢物羟基达拉非尼 (OHD)。OHD(纯度>99%)通过美迪西合成
Jun 28,2023
放射疗法用作肺癌的主要治疗方法,在次研究中建立抗电离辐射肺癌细胞系的放射治疗通过美迪西进行
Radiation therapy is used as the primary treatment for lung cancer. In this study, radiation therapy for establish ionizing radiation-resistant lung cancer cell lines (A549-IR/H1299-IR) was supported by Medicilon.
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放射疗法用作肺癌的主要治疗方法,在次研究中建立抗电离辐射肺癌细胞系的放射治疗通过美迪西进行
Jun 28,2023
索拉非尼的无定形固体分散体用于开发改良型口服生物利用度高的速释片剂,PK研究通过美迪西进行
The SOR ASD tablets exhibited approximately 50% higher relative bioavailability in dogs than the marketed SOR tablet product, Nexavar®. The pharmacokinetic (PK) study of SOR ASD tablets and Nexavar® tablets was performed by Medicilon.
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索拉非尼的无定形固体分散体用于开发改良型口服生物利用度高的速释片剂,PK研究通过美迪西进行
Jun 28,2023
TAK-931是一种高度特异性的CDC7抑制剂,具有抗肿瘤功效,体内药效研究通过美迪西进行
In vivo efficacy studies in J558 allograft models in combination with anti-mPD-1, anti-mPD-L1, and anti-mCTLA-4 antibodies were performed at Medicilon.
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TAK-931是一种高度特异性的CDC7抑制剂,具有抗肿瘤功效,体内药效研究通过美迪西进行
Jun 28,2023
GS-5801是一种有效的KDM5抑制剂,具有抗HBV活性,GS-5801通过美迪西合成
GS-5801, a potent inhibitor of KDM5, has antiviral activity against HBV in a primary human hepatocytes infection model, with the cellular permeability, oral bioavailability. GS-5801 was synthesized by Medicilon.
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GS-5801是一种有效的KDM5抑制剂,具有抗HBV活性,GS-5801通过美迪西合成
Jun 28,2023
QF-036是一种高效的HIV-1抑制剂,具有良好的和药代动力学特性,PK研究通过美迪西进行
The favourable viral inhibitory activity and pharmacokinetic properties provide critical support for QF-036 as a promising anti-HIV therapeutic candidate. The pharmacokinetic studies were performed by Medicilon.
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QF-036是一种高效的HIV-1抑制剂,具有良好的和药代动力学特性,PK研究通过美迪西进行
Jun 28,2023
SKLB-197是一种有效且高度选择性的ATR抑制剂,PK研究通过美迪西进行
SKLB-197, exhibits good pharmacokinetic properties, could be a promising lead compound for drug discovery targeting ATR. The pharmacokinetic (PK) studies were performed by Medicilon.
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SKLB-197是一种有效且高度选择性的ATR抑制剂,PK研究通过美迪西进行
Jun 28,2023
JND003是一种新型选择性ERRα激动剂,可缓解非酒精性脂肪肝和胰岛素抵抗,PK和组织分布测定通过美迪西进行
JND003 is orally bioavailable and exhibits high grade of distribution in liver and abdominal adipose tissues. Pharmacokinetics (PK) and Tissue Distribution Assays of JND003 were performed at Medicilon.
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JND003是一种新型选择性ERRα激动剂,可缓解非酒精性脂肪肝和胰岛素抵抗,PK和组织分布测定通过美迪西进行
May 29,2023
SAPA-NE | 美迪西冠名第25届年会,波士顿见!
SAPA-NE第25届年会将于6月3日在马萨诸塞州剑桥市举行,美迪西CEO陈春麟博士将带来演讲“Medicilon Strategy & 20 Years Experience for Dual Filing of IND to US FDA & China NMPA along with IPO at STAR Market”。
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SAPA-NE | 美迪西冠名第25届年会,波士顿见!
Apr 21,2023
美迪西专题研讨会开启英国之旅
美迪西2023年度英国研讨会 Medicilon’s 2023 Annual UK Symposium: New Approaches to Facilitate Drug Discovery 将于当地时间4月21日在英国剑桥科技园巴布拉汉姆研究园区举办。
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美迪西专题研讨会开启英国之旅
Feb 13,2023
来,和ChatGPT聊聊CRO那些事
Medicilon 是一家靠谱的CRO,具有丰富的研发经验和资深的专业团队。他们拥有卓越的技术和设施,并严格遵守各项法规和标准,为客户提供高质量的研究服务。此外,他们还获得了多项荣誉资质,证明了其在行业中的实力和影响力。
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来,和ChatGPT聊聊CRO那些事
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