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    SKLB-YTH-60可改善博来霉素诱导的肺纤维化小鼠模型中的炎症和纤维化，YTH-60的体内药代动力学研究通过美迪西进行

    2023-07-06
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    Idiopathic pulmonary fibrosis is a chronic and lethal lung disease associated with fibroblast activation, myoblast proliferation and extracellular matrix deposition. SKLB-YTH-60 was developed through computer-aided drug design, de novo synthesis and high-throughput screening. YTH-60 has obvious anti‐proliferative activity on fibroblasts and A549 cells. YTH-60 has an acceptable oral bioavailability and appropriate eliminated half-life time.  The in vivo pharmacokinetic study of YTH‐60 was performed by Medicilon.

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    Reference:

    Hongyao Liu, et al. A novel multikinase inhibitor SKLB-YTH-60 ameliorates inflammation and fibrosis in bleomycin-induced lung fibrosis mouse models. Cell Prolif. 2021 Jul;54(7):e13081. doi: 10.1111/cpr.13081. 

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