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开发一种简单准确的液相色谱串联质谱法，用于大鼠血浆中牡荆素鼠李糖苷的测定和体内PK研究。此研究中动物研究通过美迪西进行

2023-07-06
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A simple and accurate liquid chromatography coupled with tandem mass spectrometry method was developed for determination and in vivo pharmacokinetic studies of vitexin rhamnoside in rat plasma. Practical utility of this new LC/MS/MS method was confirmed in pilot pharmacokinetic studies in rats following both intravenous and oral administration. Animal studies were carried out in Medicilon.

Reference:

Mingjin Liang, et al.  Quantitative LC/MS/MS method and in vivo pharmacokinetic studies of vitexin rhamnoside, a bioactive constituent on cardiovascular system from hawthorn. Biomed Chromatogr. 2007 Apr;21(4):422-9. doi: 10.1002/bmc.777.

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